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May 1, 2025

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The Endeavor45 Story: Patients are waiting

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By: John Alleman

Endeavor45 was founded when after spending 25+ years in the orthopedic device industry in a multitude of roles, John Alleman questioned how new and meaningful orthopedic innovations were going to be developed and delivered; who would take the reins and drive these critical ideas through the complicated and risk-laden development process?  John knew that patients were waiting for these advancements.  

Could a hyper-specialized company provide a path in early-phase development and initial commercialization? At 45, John decided it was finally time to pursue his mission in a new way.  Innovation simply can’t be a thing of the past. John firmly believed that with amazing people, proven expertise, and purpose-built methods, Endeavor45 could lead the way in a new era of medical device innovation.  

By 2016, the greater orthopedic device industry had grown and changed; the method for developing new innovative devices was different.  No longer was it standard for the large, medium, or even small companies to develop new products internally.  Device companies were finding the older methods were slow, expensive, and not flexible for rapidly changing market and company goals.  Market forces pushed established companies to seek innovation and development from outside.  Higher risk, extensive time, high costs, and a robust competitive focus on commercialization, health system contracting, and desire for rapid indication diversification led many companies to look for better and less risky ways to stay innovative and relevant.  

At the same time, surgeons, engineers, and industry experts with new and innovation ideas were clamoring for a reasonable pathway to develop their innovations and have them readily accessible to patients.  Given the afore mentioned corporate changes, founders and innovators we left to seek new and more risky ways to develop their ideas.  Understanding the deep complexity and multitude of varied expertise required founders seemed to be left to go it alone; high-risk, high-cost, and low probability of success looked probable.  Endeavor45 was built to solve this challenge.  We are a proven innovation and venture firm.  Let’s innovate together.

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John Alleman

Founder & CEO

John, a lifelong entrepreneur with a passion for biology, has dedicated over 25 years to the orthopedic and medical device industry. After gaining extensive experience across various companies, he founded Endeavor45 at age 45 to deliver meaningful innovations to medicine, driven by the belief that patients are waiting for better solutions.

Let's build something amazing together

Have a medical device idea? Wherever you are in the development journey, we’d love to hear from you. No idea is too small and it’s never too early. Let’s explore it and see how we can bring your ideas to reality.